Opening Day 2025 Yankees. The yankees will open up their season against the houston astros, and the game will take place at 4:10 pm edt on match 28. The new york yankees will open the home portion of their 2025 regular season schedule on friday, april 5, at 1:05 p.m.
The 2025 schedule is out! Yes, the yankees will begin 2025 on the road against their frequent postseason tormentor, the astros, while the home opener is set for april 5 against the blue jays.